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I am a PhD candidate in the School of Life Sciences at the University of Technology Sydney (UTS), supervised by Professor Brian G. Oliver. My doctoral research focuses on elucidating the therapeutic potential of lung-derived extracellular vehicles (EVs) in the treatment of dust-induced lung diseases, including silicosis and pneumoconiosis. Through a combination of in vitro and in vivo models, my work aims to characterize how EVs regulate inflammation, fibrosis, and tissue repair in the lung microenvironment.
Prior to my PhD, I completed a Master of Philosophy (MPhil) in Medicine at the University of Sydney. My research investigated the roles of sex chromosome-linked genes (ZFX, ZFY, and RPS4Y1) in modulating inflammatory responses and corticosteroid sensitivity in asthma. Using CRISPR-Cas9 knockout models and cytokine profiling, I identified distinct regulatory mechanisms through which these genes influence NF-κB activation and sex-specific inflammatory signaling.
Overall, my research interests center on the molecular regulation of inflammation, steroid resistance, and the development of novel EV-based therapeutic strategies for chronic lung diseases.